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Derginin Adı: Theoretical & Applied Science
Cilt: 2015/29
Sayı: 9
Makale Başlık: SURVEY THE LOCAL ANESTHETIC DRUGS MECHANISM AND ITS EFFECT ON SODIUM VOLTAGE CHANNEL
Makale Alternatif Dilde Başlık: SURVEY THE LOCAL ANESTHETIC DRUGS MECHANISM AND ITS EFFECT ON SODIUM VOLTAGE CHANNEL
Makale Eklenme Tarihi: 20.12.2015
Okunma Sayısı: 0
Makale Özeti: Abstract: The transmission of nerve impulses inside of axon done by action potential wave and pain is felt in body. Since the sodium ions have a key role in production of action potential wave, in order to prevent of pain feeling creation, we use local anesthetic drugs, because they have ability to prevent of entry of sodium ions into axon and also prevent of production and propagation of action potential wave inside of axon. Hence, in this paper three kind of local anesthetic drugs base on lasting effect, structure and some properties of them in order to produce local anesthetic have been explored. Also action mechanism of these drugs and how they can effect on sodium channel and some common methods of local anesthetic production presented. Finally, it can be seen that by using local anesthetic drugs, sodium channels blocked and the action potential will not be producted and propagated inside of the axon. As a result, the body doesn’t feel pain and local anesthetic occur.
Alternatif Dilde Özet: Abstract: The transmission of nerve impulses inside of axon done by action potential wave and pain is felt in body. Since the sodium ions have a key role in production of action potential wave, in order to prevent of pain feeling creation, we use local anesthetic drugs, because they have ability to prevent of entry of sodium ions into axon and also prevent of production and propagation of action potential wave inside of axon. Hence, in this paper three kind of local anesthetic drugs base on lasting effect, structure and some properties of them in order to produce local anesthetic have been explored. Also action mechanism of these drugs and how they can effect on sodium channel and some common methods of local anesthetic production presented. Finally, it can be seen that by using local anesthetic drugs, sodium channels blocked and the action potential will not be producted and propagated inside of the axon. As a result, the body doesn’t feel pain and local anesthetic occur.

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